NSAIDS produce ulcerogenic actions because

Question

Question

This question was previously asked in

ISRO Pharmacist Previous Year Question paper 2021

Answer 1

Correct Answer: None of the above

Rationale:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to cause gastrointestinal (GI) ulceration and bleeding primarily due to their mechanism of action.
NSAIDs inhibit the cyclooxygenase (COX) enzymes (COX-1 and COX-2). COX-1 produces prostaglandins that help protect the stomach lining by promoting mucus and bicarbonate secretion and maintaining mucosal blood flow.
By inhibiting COX-1, NSAIDs decrease the production of protective prostaglandins, leading to reduced mucus secretion, bicarbonate secretion, and mucosal blood flow. This diminishes the stomach's protective lining, making it more susceptible to damage from gastric acid, resulting in ulceration.

Explanation of Other Options:

They decrease acid secretion in stomach

This option is incorrect because NSAIDs do not decrease acid secretion in the stomach; instead, they reduce the protective mechanisms of the stomach lining.

They increase mucus secretion in stomach

This option is incorrect because NSAIDs actually decrease mucus secretion, which contributes to their ulcerogenic effects.

They increase mucosal blood flow in stomach

This option is incorrect because NSAIDs reduce mucosal blood flow, which is part of the protective mechanism impaired by COX-1 inhibition.

Conclusion:

The ulcerogenic actions of NSAIDs are due to the inhibition of protective prostaglandins rather than any effects mentioned in the options. Therefore, the correct answer is option 4: None of the above.